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Dimethyl fumarate induces coordinated DNA methylation changes in circulating leukocytes (including CD4+ T cells and monocytes), while interferon-β produces targeted, cell-type-specific methylation shifts, demonstrating that MS-relevant epigenetic programs are reversible and may be corrected in tandem with the restoration of one-carbon flux (138,144-146)
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doi: 10.1186/ar2783 21 CohenSKamarckTMermelsteinR
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