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Notably, single-cell RNA sequencing (scRNA-seq) analysis of severe AH livers revealed that hepatic stellate cells produce CXCL5, while hepatocytes express CXCL6 [75]

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In autoimmune diseases, such multi-component immune responses may be more complex, as the patient’s immune system has already mounted abnormal responses to multiple self-antigens and might more readily recognize and attack different components of the ADC [128]