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Pharmacologically, glutamine deprivation by glutamine analog DON leads to the induction of EMT through selectively up-regulating the EMT transcription factor Slug in both KPC mouse model and human PDAC cell lines, contributing to enhanced tumor migration and invasion capacities (111)
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[9] Visual disturbances have been reported in patients with Leber hereditary optic neuropathy, and rapid B12 administration may precipitate optic nerve atrophy in this genetically predisposed population, mandating extreme caution or alternative therapy
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