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Pretreatment of peripheral blood mononuclear cells from patients with MS with curcumin reduced IL-12 production and enhanced production of IL-10 induced by IFN-β ( in vitro and in vivo studies showed the effectiveness of curcumin against the pathogenetic mechanisms of MS, and although further evidence from randomized controlled trials on curcumin efficacy is required, its role as an effective alternative treatment was suggested ( Ginkgo biloba The study of Noroozian et al
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