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Effects of ras and von Hippel-Lindau (VHL) gene mutations on hypoxia-inducible factor (HIF)-1α, HIF-2α, and vascular endothelial growth factor expression and their regulation by the phosphatidylinositol 3'-kinase/Akt signaling pathway

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Compared with the Sham group, levels of ROS in lung tissue increased obviously after exposure to silica for 7 d and 28 d (Figure 3A–D), suggesting that silica continued to induce severe oxidative stress in lung tissue