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Phycocyanobiline decreased pro-inflammatory cytokines (IL-17, IFN-γ, and IL-6) and markers related to apoptosis in the brain [194] and the spinal cord [195], and reduced demyelination, active microglia/macrophages density, and axonal damage and increased oligodendrocyte precursor cells and mature oligodendrocytes in the spinal cord of 8–10 week-old female C57BL/6 mice with EAE [195]
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Phosphorylated Grb14 is an endogenous inhibitor of retinal protein tyrosine phosphatase 1B, and light-dependent activation of Src phosphorylates Grb14
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