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FIGURE 5 The Effect of GSTP1 on AQ-QI- and DEAQ-QI-Induced Alteration on Cellular GSH Homeostasis To evaluate whether cellular GSH homeostasis was affected by QIs, and whether GSTP1 did influence the effects, concentrations of intracellular GSH and GSSG were quantified following exposure to synthetic AQ-QI and DEAQ-QI
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Nonetheless, the SAINT-II trial, a larger trial that sought to support SAINT-I trial results, concluded that NXY-059 is ineffective for acute ischemic stroke when administered 6 hours after onset [62]
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