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While Nrf2 signaling is often suppressed globally in COPD lungs, its dysfunction in macrophages may paradoxically promote ferritinophagy-mediated iron retention through nuclear receptor coactivator 4 (NCOA4), overwhelming ferroprotein (FPN)-mediated iron export and unintentionally fueling ferroptosis
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Strength:1mg (60 count)
mGPDH has also been implicated in diseases such as type 2 diabetes and nonalcoholic fatty liver disease 56,57,58
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