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In spite of their limitations, these studies are the first to demonstrate a capacity of exogenously administered NAC to reach the CNS
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Emerging therapeutic strategies aimed at overcoming Nrf2-driven ferroptosis resistance include the use of inhibitors such as triptolide and brusatol, which impair antioxidant defenses and sensitize isocitrate dehydrogenase 1 (IDH1)-mutant gliomas to ferroptotic cell death [69]
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