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Another point of interest regarding B12 supplementation is the commonly held belief that intramuscular injections of B12 are more effective than oral supplementation

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Although, to date, a complete understanding of physiological conditions that may create reductive stress have not been elucidated, conditions, such as hypoxia, hyperglycemia, and other stresses that inhibit mitochondrial function, are known to cause excess accumulation of cellular reducing equivalents (199, 270, 358)