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TMC also increased the permeability of the hydrophilic markers, [ 14 C]-mannitol and [ 14 C]-PEG 4000, in vitro , with greater effects observed for lower molecular weight solutes (Kotze et al., 1998

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Inquiry should be made regarding a history of kidney stone , since a patient with gout and kidney stones will likely require faster and more aggressive lowering of uric acid (see below) than one without stones, to try and prevent recurrent stone formation